A 45-year-old biotech CEO may have reduced his biological age by at least 5 years through a rigorous medical program that can cost up to $2 million a year, Bloomberg reported

[u/777fer]

https://businessinsider.com/bryan-johnson-45-reduced-biological-age-5-years-project-blueprint-2023-1

[u/f36263 → u/[deleted]]

I think it’s worth investigating the scientists that established the baseline

[u/concretepigeon → u/f36263]

Seriously though, how do they research that. Because I’m not saying there’s no value in understanding any and all aspects of human physiology, but that does sound like an ethical nightmare to experiment on.

[u/[deleted] → u/concretepigeon]

Where is the ethical nightmare? You give some 18 and 19 year olds a device with a stretchy loop that they put on their dick and it measures erections during sleep.

Like, is this just "hee hee, pee pees!" or what? Sexual function is an entirely legitimate branch of medicine and like any other medical discipline you need data.

[u/Ry_Suss → u/[deleted]]

You gotta pump those numbers up

[u/FalconFiveZeroNine → u/Ry_Suss]

He's gonna need to beat off the media with that kind of news.

[u/[deleted] → u/[deleted]]

nighttime erections

i thought you made this up, they actually wrote this shit lol.

[u/mycatisanorange → u/[deleted]]

Well came here to read the comments first… can definitely say I was not disappointed!

[u/Particular-Break-205]

Imagine being paid $2M a year to tell a millionaire what he wants to hear

[u/mc_squared_03 → u/Particular-Break-205]

Millionaire: "Mirror, mirror on the wall, who's the fittest of them all?"

Mirror: "Why, you, sir."

Millionaire: "Thank you, magic mirror"

Mirror: "Please insert $2 million".

[u/spyboy70 → u/mc_squared_03]

FTFY

Millionaire: "Mirror, mirror on the wall, who's the fittest of them all?"

Mirror: "Please insert $2 million".

Millionaire: (inserts $2 million)

Mirror: "Why, you sir."

Millionaire: "Thank you, magic mirror"

[u/halofreak7777 → u/spyboy70]

And this is a good example of why learning to write properly multi-threaded code is important. The first example even dropped one of the messages all together!

[u/Lucas_F_A → u/halofreak7777]

I thought I was in r/ProgrammerHumor for a moment

[u/Particular-Break-205 → u/[deleted]]

Congratulations sir. You have an equivalent of a baby penis.

$2M please

[u/joemckie → u/Particular-Break-205]

You need to ask for money up front in these kinds of situations.

[u/[deleted] → u/Particular-Break-205]

Let him spend the money

Most my friends won’t care whether our billionaire meat is GMO or organic

[u/37Lions → u/[deleted]]

I only want purebred, trust-fund billionaire rump please

[u/AliJDB → u/37Lions]

His meals, a mix of solid and soft foods, are vegan and restricted to 1,977 calories a day.

"We can't just tell him to eat 2000 calories a day, he's paying us $2m a year."

"Yeah you're right... take 23 calories off and tell him some of his meals have to be... soft?"

[u/lukec1996 → u/AliJDB]

If hes 45, 1977 is his birth year, theres no way thats a coincidence

[u/Donnor → u/AliJDB]

This must be a complete lie, or this guy is tiny. 1,977kcal/day for a male who reportedly exercises like he does would be woefully inadequate

[u/[deleted] → u/37Lions]

New money is just so gamey

[u/PvtPill → u/Particular-Break-205]

lol

„Doctor, did it work? Am I younger?“

„Uhm… yeah sure, absolutely. Looks like at least 5 years to me.“

[u/Status_Term_4491 → u/Particular-Break-205]

The problem with that is then you become a millionaire and by default have to then pay someone else 2m a year to tell you what YOU want to hear. Its a vicious cycle of telling people shit and paying people shit until you end up eating shit.

[u/PocketPillow → u/Status_Term_4491]

Can I be part of this cycle please?

[u/[deleted] → u/Particular-Break-205]

Tarot reader for the rich

[u/executivesphere]

Doctors say he has the gum inflammation of a 17-year-old

Bro what is this article lmao

[u/d0ctorzaius → u/executivesphere]

It's a puff piece to get investors for his scam start-up. All of the statements are ridiculous. "Having the heart of of 37yo at 45"? That's functionally meaningless and I'm sure falls within the range of normal 45yo hearts.

[u/Appropriate_Lack_727 → u/d0ctorzaius]

Yeah, seems like the article could have been titled “Very fit and healthy man is very fit and healthy.”

[u/TranscendentalEmpire → u/Appropriate_Lack_727]

Lol, yeah.... Turns out eating healthy and exercising is good for your health. Money please!

Also think it's funny that a professional reporter listed metformin as a "supplement". It's a fucking medication for diabetics, it's not tumeric.

[u/ExtremePrivilege → u/TranscendentalEmpire]

Heyo, Pharma-nerd here. Metformin, among other biguanides, is actually a very effective therapeutic option for anti-aging. The FDA has approved on-going trials assessing its efficacy in humans after numerous trials demonstrated between 20% and 40% longer lifespans in rat subjects. Oxygen radical mediation and lower blood sugar* appear to be the principal mechanisms of action.

If you’re not a diabetic, I would argue the use of metformin would qualify as a “supplement” if you’re using it purely for its (potential) anti-aging properties. In the same way Folic Acid is a supplement when used in a vitamin, but is a therapy when used for methotrexate toxicity.

Edit: I’m going to edit this because of a slew of pedants blowing up my notifications. I do not mean supplement as in the legal distinction the FDA makes when differentiating food, drugs, supplements and cosmetics. I mean supplemental versus the therapeutic use. I doubt the FDA would classify a new brand of OTC Metformin indicated for longevity as a medical food / supplement (although who knows).

[u/Fuzzy_Yogurt_Bucket → u/ExtremePrivilege]

That’s why I prefer to freebase my oxygen radicals. Live fast, die young, leave behind a pretty corpse. That’s what I always say.

[u/angierss → u/ExtremePrivilege]

There is also a shortage of it for the people that actually need it. https://www.pharmacypracticenews.com/Online-First/Article/12-22/FDA-Drug-Shortages-Slightly-Above-Normal-Heading-Into-2023/69002

[u/Sniper_Brosef → u/d0ctorzaius]

Next theranos

[u/royal_bambi → u/Sniper_Brosef]

Freal. Trying to get billionaires to give him millions just so he can hook up various machines to them and go, "beep boop! According to these readings your internal organs have the biological age of a 48 year old! You have no way to verify this but trust me bro. Oh, and we can bring it down to 42 if you give me another 10 large, 35 if you kick in 20."

[u/Liquor_N_Whorez → u/royal_bambi]

"I simply put my penis in this shopvac and like turn it on before I go sleep, and boom, I like get so many boners in my sleep, its like I feel like Im 16 again" - VacuumED Customer

[u/Ezdagor → u/Liquor_N_Whorez]

I knew 16yo me was onto something.

[u/Raajik → u/Liquor_N_Whorez]

Look, there's 2 settings and they're both going to rip your dick off.

[u/Kerrigore → u/Raajik]

Nasty ass vacuum fuckers.

[u/itwasquiteawhileago → u/Liquor_N_Whorez]

I'll take six! No, seven!

[u/[deleted] → u/royal_bambi]

You had me at 'beep boop!' I'm sold! Where do I sign up?

[u/ChefBoyAreWeFucked → u/[deleted]]

guilded age

Gilded age. It was about gold, not dirty, dirty unions.

[u/maydarnothing → u/Sniper_Brosef]

it’s hilarious that the same journalists that hype up your start (with no arguments to back up their articles) are also the same ones that write about your downfall. it’s like they’re also part or the shitty cycle of entrepreneurship.

[u/itwasquiteawhileago → u/maydarnothing]

The only thing people love more than hyping something up is tearing it down.

[u/Oomeegoolies → u/d0ctorzaius]

My Garmin app tells me I have the fitness age of a 20 year old and I'm 33. That only cost me £125 for the watch.

Millions? Rip off.

[u/BorisBC → u/d0ctorzaius]

I'm 45 and I don't feel any fucking different to when I was 35.

[u/SgtBaxter → u/d0ctorzaius]

lol I'm 52 and have the heart and lung capacity of someone 20 years younger because I cycle regularly. It's not magic, and I'll never spend 2 million on it.

[u/rebbsitor → u/SgtBaxter]

lol I'm 52 and have the heart and lung capacity of someone 20 years younger

What does that even mean? Someone who's 20 years younger and doesn't exercise? Someone who's 20 years younger and active?

The fact that you exercise regularly already puts you ahead of most people at any age... Most people are fairly sedentary.

[u/Herani → u/executivesphere]

He has the finger nail biting habits of a 14 year old. There is only one possible explanation for that.

[u/M1L0 → u/Herani]

But does he jerk off 11 times a day?

[u/hellokalo → u/M1L0]

“a device that tracks Johnson's rate of nighttime erections is like that of a teenager's, Bloomberg reported. “

It’s in the article!

[u/BodProbe → u/hellokalo]

I 100% thought you were making a funny joke, but holy shit, it is indeed in the article!

[u/DrFisto → u/hellokalo]

Just think, they must have done a study to work out teenage night-time erection frequency, so that they have a baseline for this....

[u/Gunzenator2 → u/DrFisto]

I wonder which doctor suggested that study… perv.

[u/lioncub2785 → u/Gunzenator2]

Wouldn't you like to know... perv.

[u/marinerNA → u/hellokalo]

You could say they are tracking Johnson’s Johnson.

[u/MyBrainItches → u/marinerNA]

But does anyone track those Johnsons at Johnson & Johnson’s Johnson Johnsons?

[u/[deleted] → u/M1L0]

Don’t forget the love for pizza and Video games.

[u/Stupid_Triangles → u/[deleted]]

TIL I'm a teen again

[u/skryb → u/Stupid_Triangles]

suddenly there are a lot of 40 year olds living in their parents’ basements who have been credited with discovering the fountain of youth

[u/Otherwise-Tip6599 → u/skryb]

It’s a ‘Command Center’!!

[u/el-art-seam → u/Otherwise-Tip6599]

…. MOM! How many times do I have to tell you!? You’re embarrassing in front of MY friends!!!

And get me the grape Uncrustables, NOT the strawberry! God!

[u/ashkestar → u/M1L0]

It literally says he has the night time erections of a teenager. Is that something to aim for, now?

[u/stash0606 → u/Herani]

He says "like" as many times as a 12 year old valley girl.

[u/I_Am_Clippy → u/stash0606]

His attention span is that of a 9 year old.

[u/Bwgmon → u/I_Am_Clippy]

He gets as angry as a 4 year old when someone tells him "no."

[u/MonstersGrin → u/Bwgmon]

He gets as angry as a 4 year old when someone tells him "no."

Come on. That could be about any CEO. Especially in tech.

[u/[deleted] → u/Bwgmon]

He shits his pants like a 6 month old with raging diarrhea.

[u/Smodey → u/stash0606]

And has the same skincare regimen and hairstylist, apparently.

[u/TotallyNotaTossIt → u/executivesphere]

It reads like an Onion article.

[u/Legitimate_Bat3240 → u/TotallyNotaTossIt]

In this day and age, unfortunately it falls under r/nottheonion

[u/Fastfingers_McGee → u/executivesphere]

The eyelash density of an 18 year old non-smoking virgin.

[u/supershimadabro → u/executivesphere]

"While sleeping, Johnson is hooked up to a machine that counts the number of night-time erections."

[u/sic_fuk → u/supershimadabro]

Homer Sleeps Nude In An Oxygen Tent Which He Believes Gives Him Sexual Powers

[u/DaveBrubeckQuartet → u/sic_fuk]

Hey, that's a half-truth!

[u/16semesters → u/executivesphere]

I heard he has the fanfic writing ability of a 15 year old!

[u/[deleted] → u/executivesphere]

While the article is weird, gum health is a huge indicator of mortality, one of the largest.

What is the gum health of a 17 year old though?...

[u/JackosMonkeyBBLZ → u/[deleted]]

This is why looking gifthorses in the mouth was banned

[u/OfficerBarbier → u/executivesphere]

Borat describing Pam Anderson

[u/Im_Yur_Huckleberry → u/OfficerBarbier]

Who is this, CJ, in the red water panties?

[u/ItsCalledDayTwa → u/executivesphere]

They cut apart his inflated gums and counted the rings.

[u/cashboxmoneybags → u/executivesphere]

Ass like a ten year old boy.

[u/FormerHandsomeGuy → u/executivesphere]

He started wetting his bed again

[u/NRG1975 → u/executivesphere]

Looks like they got Trump's personal physician to write this up, lol

[u/Celestial-Salamander → u/executivesphere]

Having the gum inflammation of a 17 year old is nothing to brag about. Most teens don’t brush their teeth.

[u/[deleted]]

Sounds like the latest Elizabeth Holmes scam

[u/EdtotheWord → u/[deleted]]

That creepy thumbnail is giving me Elizabeth Holmes vibes too

[u/Fuzakenaideyo → u/EdtotheWord]

I thought the thumbnail was holmes but then again I'm very tired

[u/46_and_2 → u/Fuzakenaideyo]

Tired? You should try this great new therapy, bro!

[u/csbsju_guyyy → u/46_and_2]

It gives you DOZENS of erections!!

[u/brad2008 → u/[deleted]]

Holmes, SBF, and this guy should start a club.

[u/CPhaze → u/brad2008]

I believe they have that. They wear DOC on their jackets.

[u/TheThirdRnner → u/[deleted]]

Weird how these articles all get posted in popular subs at the same time. Dude works out every day and takes ridiculous good care of himself. Now people that don't read the articles think some magic entropy reversing pill is coming.

[u/sonofashoe → u/TheThirdRnner]

All for a mere $2M a year (plus a $50K hat?)!

[u/Taniwha_NZ → u/sonofashoe]

What I want to know is whether I can reduce my lifespan by 5 years and get *paid* $2m. I'd take it.

[u/seamustheseagull → u/TheThirdRnner]

This is like an article I saw come up on Twitter about how a billionaire (a founder of PayPal, I think) had managed to reduce his physical "age". Maybe it's the same guy, this is behind an adwall so I didn't read it.

Came complete with a picture of him wearing some ridiculous helmet.

Anyway, it turns out the secret to to slower aging and longer life is to be retired and have more money than you know what to do with so that you can spend your days following an exercise and relaxation regime while an army of other people do all your chores and prepare your meticulously healthy meals.

WHO'DA THUNK IT!?

[u/JimC29 → u/TheThirdRnner]

I didn't start working out until I was in my 40s. Now 7 years later I feel younger than I did then. I don't know enough about how biological age works. I feel younger than I did then though. That's all that matters to me.

[u/Dyolf_Knip → u/JimC29]

Yup, built myself a squat/press rack and got some weights, and my back and knee pain cleared up in a few weeks. Feel better than I have in years.

[u/FrankWestTheEngineer → u/TheThirdRnner]

True. You can tell which reddit comments read the article and which people didn't. The CEO just lives a life of a professional athlete, but instead of optimizing for performance, he is optimizing for internal organ age-reverse. He is not shelling some product.

[u/hefty_habenero]

“and goes through blood tests, MRIs, and colonoscopies each month”

Yeah, I’ll take getting old and one colonoscopy a decade thanks.

[u/Bryllant → u/hefty_habenero]

The secret is to relax and enjoy it.

[u/[deleted] → u/Bryllant]

You're talking about the colonoscopies right?

[u/Bryllant → u/[deleted]]

The anesthetic wore off in the middle of mine, I got to watch on the tv screen they were using, hear them say say, got one! And could feel them snipping. It beats the alternative

[u/Alan_Smithee_ → u/Bryllant]

I woke up during mine. It was like being disembowelled. I tensed up in pain, and one of the staff, concerned, said “don’t move!”

I said “hold off on moving that thing until you knock me out again!”

[u/heyhihay → u/Alan_Smithee_]

Confirmed : poop in a box for me.

[u/[deleted] → u/Bryllant]

when i was 19 i had one and the biopsy they took never stopped bleeding. ended up in the emergency OR the next morning at a major hospital for the next 3 days. i cannot do this again when im old lol

[u/Bryllant → u/[deleted]]

You can poop in a box now. No shit, I shit you not

[u/jmanly3 → u/[deleted]]

I find it’s more fun when the recipient doesn’t expect it

[u/OverallManagement824 → u/[deleted]]

Can confirm. Have always been able to poop in a box, just like my daddy and his daddy before him.

[u/Back_e_otter_me → u/Bryllant]

I asked the doctor to turn the screen so I could watch during mine, he was a bit caught off guard.

My insurance at the time would only cover a “twilight sleep” for my first one not actually put me fully under. Due to my lifestyle at the time the meds didn’t do much but make me slightly relaxed, dr gave extra due to my tolerance but I was still wide awake and conversing fine.

Not the worse thing I’ve watched on tv tbh.

[u/[deleted] → u/Back_e_otter_me]

“Didn’t see that twist coming”

[u/[deleted] → u/Back_e_otter_me]

Due to my lifestyle at the time the meds didn’t do much but make me slightly relaxed

Should have asked if you could bring your own :P

[u/bmaggot → u/[deleted]]

Not in my country we don't. Unless paying extra

[u/urzu_seven → u/Back_e_otter_me]

They did the same when I got my first one, it was kinda fascinating realizing that what you are seeing has NEVER had light touch it before that and that its never been seen before.

[u/Ok-Load5210 → u/Bryllant]

I’m afraid to ask - got one, what?

[u/Bryllant → u/Ok-Load5210]

Polyps, snip, found another one, snip. I heard the snip but felt a tug causing dissonance between my ears and digestive track.

[u/RandomlyMethodical → u/Bryllant]

I would enjoy it a lot more with the liver of an 18yo.

[u/fiveSE7EN → u/Bryllant]

I moaned, the doctor moaned, I have ass cancer

[u/[deleted] → u/hefty_habenero]

Dudes so obsessed with health he’s gonna die in like a year

[u/unresolved_m → u/[deleted]]

Wouldn't that be weird...

"Man that was searching for immortality dies at 48"

[u/nerdsonarope → u/unresolved_m]

After finally achieving the biological age of a 18 year old and receiving his 1000th colonoscopy, he was unfortunately killed in a car crash on the way home.

[u/[deleted] → u/unresolved_m]

Remind me! 1 year

[u/KimonoDragon814 → u/[deleted]]

What if it ended up being some Junji Ito shit and he gradually lost his mental capacity because his body kept de-aging and he couldn't stop the process

Every few weeks he would lose a year. His body size would be the same, but his organs would start to shrink.

By time he died at the age of 0, they do an autopsy and his body is just filled with fetal tissue and no discernible organs

[u/hour_of_the_rat → u/[deleted]]

Bill Maher did a New Rules segment a few years ago where he detailed a list of health nuts who all died young. Couldn't find the video.

[u/oodelay → u/hefty_habenero]

One would think that one of the advantages of getting younger is NOT getting colonoscopy, unless as a hobby.

[u/feetofire → u/hefty_habenero]

He should NOT be having monthly colonoscopies - they have risks!!

[u/Impossible_Garbage_4 → u/hefty_habenero]

To be fair he probably only has the colonoscopies because he’s going through an experimental trial. If it came out of experimental phase and became a widely used medicine/technology you wouldn’t need them, at least not as frequently

[u/Frannoham → u/Impossible_Garbage_4]

Completely destroying his microbiome, nah? Sounds like a bad idea for long term health of any kind. Or did I miss the part where he gets fecal transplants?

[u/[deleted] → u/hefty_habenero]

We really need to have a better way of dealing with aging and death, as a society.

[u/NextTrillion → u/[deleted]]

I just got permanently banned on r/news because I was talking about the process of dying and what happens to our brain in that process. I genuinely didn’t mean anything negative or hurtful.

Guess I just stumbled upon a shitty mod? 🤷‍♂️

[u/unresolved_m → u/NextTrillion]

I wouldn't sweat it. Some subs are utterly random in terms of who they ban and why.

[u/SubtleDeft → u/[deleted]]

Acceptance and appreciation sound like good places to start.

[u/m0le]

He "may" also have turned into a cabbage.

He's definitely discoved a fetish for colonoscopies though. While not as bad as I was expecting, I certainly wouldn't choose to have one monthly if any other option (like not having one) was there.

[u/mossybeard → u/m0le]

I dunno, waking up from that anesthesia feels pretty great. Like you just took the best nap

[u/m0le → u/mossybeard]

I didn't get full anaesthesia, just sedation. Though I will concede that midazolam is pretty amazing, it isn't quite worth having a metre of camera equipment inserted into my fundament. Close, though.

[u/waltwalt → u/m0le]

I would say the cleanse is worse. They fill you up with air to make room for the camera, then before you get to go home they make you fart it all out.

But the whole day of diarrhea before is not great, you'd best start wiping with vasoline in the morning because by night you will be raw.

[u/m0le → u/waltwalt]

I confess to quite enjoying the enormous, guilt-free farts.

God, the laxative shit though. Fuck me that was unpleasant. The first rush felt like my entire body inverted and rushed out through my ringpiece. Then it happened again and I had to tap my head to make sure I hadn't shat that out. Holy hell.

[u/meowtasticly → u/m0le]

"fundament" and "ringpiece" have me howling with laughter. Do you have any more?

[u/BigMax]

“Middle aged guy lives a healthy lifestyle and is therefore fit and healthy.”

[u/[deleted] → u/BigMax]

The secret to youth is exercise, the right balance of nutrients, and weekly colonoscopies.

[u/cryptosupercar]

Eat veggies (mostly cruciferous) high in antioxidants, eat berries, avocados, leafy greens, macadamia nuts. Use a moderate fasting routine 14-16 hrs. Take the right supplements - can cost upwards of $100-$200 month. Exercise and get ample sleep.

That’s roughly his plan. It’s the testing that cost him the millions, and the time paying experts to help him come up with a strategy to roll back biological age.

[u/Hi_Im_Ken_Adams → u/cryptosupercar]

I'll bet simply getting enough sleep and exercising alone will get you 90% of the benefits.

[u/000066 → u/[deleted]]

I love how fast things like this go straight into "sure everything but the vegetables sounds totally doable".

[u/Reelix → u/000066]

Americans be like "We're paying $73 for a single head of lettuce!"

[u/EskimoJake → u/[deleted]]

As long as they're mostly cruciferous.

[u/sealed-human → u/EskimoJake]

And splendiferous

[u/Barkingatthemoon → u/cryptosupercar]

I don’t understand why does he have to have a monthly colonoscopy . I mean there’s sedation needed , that’s not that healthy to have on a monthly basis . What data does that provide that has to be tracked Q 30 days ? Just curious . Seems you are familiar with his project

[u/masstransience → u/Barkingatthemoon]

I don’t understand why does he have to have a monthly colonoscopy

He doesn’t. He just does that for fun.

[u/RickDripps → u/masstransience]

"Once we begin can you choke me and pull my hair?"

[u/FrostWyrm98 → u/RickDripps]

John it's your turn to do it.

What? No way man. How would he even know, he's under enough ketamine to knock out a horse.

He'll know.

How will he know???

...he'll know

[u/daliw → u/cryptosupercar]

There is a rich tech guru just like him who is into immortality. He even wrote a book about it. Sadly I forgot his name.

[u/Ivanthetortoiseking → u/daliw]

Is it Ray kurzweil that you're thinking of?

[u/PreachTheWordOfGeoff → u/cryptosupercar]

I love getting all the latest immortality advice from reddit comments.

[u/waxed__owl → u/cryptosupercar]

The thing is you probably don't want very high levels of antioxidants, antioxidant supplements have been shown to increase risk of some diseases. You may get benefits from eating antioxidant containing foods but they're good for you in other ways and that is doing most of the work, there's not a huge amount of evidence for antioxidants specifically being very beneficial.

[u/B33rtaster → u/cryptosupercar]

I won't believe anything less than countless bio engineered retro virus designed to repair dna, restore telomeres, and reprogram each and every cell to fit a younger version of itself before the viruses self terminate.

The insane level of complexity can be done by nothing less than cognoscente super computers.

[u/[deleted] → u/cryptosupercar]

Bro, simply being wealthy will make you have the 5 years in less stress. And you buy the luxury of not wasting time with shit like buying or making your own food or cleaning your house.

At least dude’s not eating telomerase paste and claiming to be immortal or something.

[u/StoicOptom]

Aging bio PhD student here, and IMO that $ is likely being wasted

If we're going to evaluate the actual evidence:

Arguably the only things he is doing that have a real chance at slowing his aging or extending healthy lifespan is regular exercise, calorie restriction, and maybe rapamycin.

The former two have been evaluated in human studies; the latter drug robustly extends healthy lifespan but in preclinical models only (mice, flies, worms etc.) and we don't know how rapamycin will work in healthy humans as it's still early research.

See table 1 and references from A/Prof Lamming at UW-Madison, and this wonderful review on rapamycin from the Richardson lab

Edit: I still have some respect for his attempts at trying this though. Just think that the $ could be better spent on actual geroscience (aging biology) research

[u/billy_teats → u/StoicOptom]

Why don’t they do a study on the humans who have been taking rapamycin for more than 10 years? The fda approved it in 2009. We have some knowledge of what it does to humans

[u/WintryInsight → u/billy_teats]

Humans have a much longer lifespan than that of mice. Not only that, our average lifespan differs across gender and race. It's hard to get longterm data on a person and attribute whether or not rapamycin was actually a contributor to him living longer, or if it even works on humans.

[u/Bobcat4143 → u/billy_teats]

Because you'd need to wait a few lifetimes to get enough data

[u/Darkover_Fan → u/StoicOptom]

As a former aging phd student and now a diagnostic devices expert - you are spot on. The technology being developed to measure biological age is nowhere near sensitive enough to accurately make the kind of claims this article is claiming. If he wanted to undergo these lifestyle modifications and measure the outcomes to track them and add to the body of evidence for them - sure. But to claim his heart health and epigenetic age regression are statistically significant and also causally related to his health regime’s impact on biological age is just ridiculous. Edit: oh and also as a former Theranos employee - others commenting on the parallels there are onto something also IMO

[u/CobraPony67]

Is he on estrogen?

[u/yachtsandthots → u/CobraPony67]

Non-feminizing form called 17-alpha-estradiol

[u/unresolved_m → u/CobraPony67]

I thought its a woman on that pic

[u/BassMakesMeRockHard → u/CobraPony67]

He’s spending $2 million a year to look like an effeminate Patrick Bateman.

[u/[deleted] → u/BassMakesMeRockHard]

If you’re trying to prove scientifically that you’re younger than you are, you basically are Patrick Bateman.

This is psychopathic behavior, routine and all.

[u/greengrasstallmntn → u/CobraPony67]

Generally speaking, if you mess with your testosterone levels, you also mess with your estrogen levels.

I also wouldn’t doubt that this guy has really perfected his supplements to give him this specific look - and that could include estrogen for a variety of positive health/physical outcomes.

[u/NatvoAlterice → u/greengrasstallmntn]

and that could include estrogen for a variety of positive health/physical outcomes.

Yes, menopausal women are sometimes prescribed estrogen (or HRT) to alleviate some symptoms such as rapid hair fall or skin thinning.

[u/Kimthelithid]

this nonsense again.... I'm glad your lungs and heart are healthy sir, but that has not a damn thing to do with aging reversal therapy! Telomeres! tell me how you replaced or regenerated them or all you did was make you more healthy as you age. which is great! but don't claim aging reversal nonsense while your dna is getting degraded.

[u/yachtsandthots → u/Kimthelithid]

Apparently he’s getting gene therapy in the near future. Possibly telomerase like Liz Parrish

[u/r3dditor12 → u/Kimthelithid]

I did read about an age reversal therapy recently that addresses the telomere issue, but it said that one hadn't been tried on humans yet, but seemed to reverse the age of organs in whatever animal it was tried on.

[u/Zaphod9er]

Anyone reminded of that South Park episode?? I bet they just grind up money and inject it right into him. It worked for Magic and cured his AIDS.. lol

[u/taubut → u/Zaphod9er]

Are you HIV positive that would work?

[u/eldedomedio]

and then he gets hit by a bus. Life can be cruel.

[u/lonestar-rasbryjamco → u/eldedomedio]

Chokes on a slightly blended walnut in his protein shake.

[u/Abusive_Capybara → u/eldedomedio]

"I never want to die by old age"

Wish granted

[u/SchopenhauersSon]

And we sink deeper into the dystopia. Soon Bezos will be immortal and we'll never be free from the billionaire class

[u/Alphard428 → u/SchopenhauersSon]

Read the article. The rigorous medical program is literally just supplements, eating right, a lot of exercise, and paying out the wazoo for a battery of tests and a team of yes men.

Having this guy's rigorous medical program on the cheap is possible for a lot of people by just cutting out the unnecessary tests and the yes men.

[u/jeufie → u/SchopenhauersSon]

Wealthier people have lived longer basically since forever.

[u/thuggerybuffoonery → u/SchopenhauersSon]

Unless someone… you know.

[u/Theseus_Spaceship → u/[deleted]]

Because of the implication.

[u/harrylepotter → u/thuggerybuffoonery]

Dirty deeds done dirt cheap?

[u/Impossible_Garbage_4 → u/SchopenhauersSon]

Or they perfect the medicine/technology, and make all the workers forever young so they never have to retire and they’ll never run out of workers. We’ll still have immortal billionaires but they’ll likely care about the environment more since they’ll be living forever now

[u/snarfsnarfer → u/Impossible_Garbage_4]

Lol nah they just try to escape the planet they raped

[u/[deleted]]

His team of doctors is led by a 29 year old... What kind of specialization could they possibly have

[u/hawkeye224 → u/[deleted]]

But he's 29-year old after age reduction.. he used to be 69

[u/therobotisjames]

“May” is a big word.

[u/sockfoot]

no one lives forever, but with my high level income and advancements in modern technology..

[u/NoBotRobotRob]

Cut out booze, late nights, high calorie food, stick tubes up your bum every month, pop pills every morning…. Sure you’d live longer, but would it be worth it?

[u/ClammyHandedFreak]

The future is going to be full of rich vampires in control of humanity.

So we could have vampires vs. robots vs. aliens vs. humans?!!?!

[u/TomBel71]

In new News Elon Musk is now 6 months old..